Alcoholism is a common substance-abuse disorder that leads to significant medical complications. Alcohol affects virtually every organ system, and alcoholics are at increased risk for cirrhosis, gastrointestinal (GI) bleeding, pancreatitis, cardiomyopathy, trauma, mental health disorders, and a wide variety of cancers. Patients frequently have very poor insight into their addiction—a state commonly referred to as denial—and must be made aware of the numerous devastating short- and long-term complications of alcohol abuse. Shown is a large hepatocellular carcinoma. Patients with viral hepatitis who abuse alcohol significantly increase their risk for cirrhosis and ensuing hepatocellular carcinoma.